Cisplatin nephropathy
WebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... WebCisplatin ATN AKI, hypomagnesemia, renal sodium Chronic interstitial fibrosis and cyst formation wasting, CKD Ifosfamide ATN Fanconi syndrome (partial or complete) AKI ESRD Methotrexate Crystal nephropathy Nonoliguric AKI Pemetrexed ATN AKI AIN CKD Tubular atrophy and interstitial fibrosis Nephrogenic diabetes insipidus Ipilimumab AIN AKI
Cisplatin nephropathy
Did you know?
WebMyeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins. Myeloma-like cast nephropathy (MLCN) has … WebJan 1, 1996 · CsA nephropathy was introduced as a PRD in the ERA-EDTA Registry in 1985 and, despite its rarity, is of particular interest as a new iatrogenic entity resulting from CsA administration, mainly in solid organ transplantation. In 1985, two new patients commenced RRT in Europe, and the number increased to 59 in 1991–93.
WebOct 22, 2024 · Cisplatin is a commonly used anticancer drug, but nephrotoxicity is a dose-limiting adverse effect. Recent experimental and clinical observations have demonstrated that multiple injections of... WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular …
WebJan 11, 2024 · Malignant obstructive nephropathy in MIBC does not usually resolve with complete transurethral resection of the tumour alone or with cisplatin-based neoadjuvant chemotherapy 82,83 and might ... WebCisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial
WebOct 6, 2016 · Cisplatin [Cis-diamminedichloroplatinum (II)] is the most nephrotoxic chemotherapeutic drug, discovered over four decades ago. Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who receive cisplatin combination chemotherapy.
WebAug 14, 2024 · Nephrotoxicity associated with cisplatin administration is common and unwanted adverse effect which has significantly restricted its clinical use [ 1 ]. Both acute and chronic nephrotoxicities associated with cisplatin tend to occur more frequently at higher doses or especially after repeated administration [ 2 ]. howard leight ear plugs quietWebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced... how many joules to boil waterWebDec 13, 2024 · Cisplatin and carboplatin are platinum-based antineoplastic agents. Approximately 30% of patients receiving cisplatin have acute kidney injury (AKI), and it is not unusual for subsequent treatment to be limited [].On the other hand, carboplatin, which was developed as a derivative of cisplatin in the same platinum formulation, is … how many joules to penetrate skinWebCisplatin is an important chemotherapeutic drug for the treatment of solid tumors but often causes nephropathy as part of the off-target toxicity. Iron accumulation and related damage were implicated in cisplatin-induced kidney injury. how many joules surge protector for tvWebAug 1, 2007 · Cisplatin nephrotoxicity primarily causes tubulo-interstitial lesions. In animal models cisplatin damages the proximal tubules, specifically the S3 segment of the outer medullary stripe. Mitochondrial swelling and nuclear pallor occur in the distal nephron. The glomerulus has no obvious morphologic changes.49., 56., 59. howard leight impact ear protectionWebJul 7, 2007 · Despite the clinical effectiveness of cisplatin as an anti-tumour drug, its nephrotoxic side effect has significantly restricted its use. In spite of prophylactic … how many joules to protect microwaveWebOct 1, 2024 · We identified Compound-6c(Cpd-6c) as having the best activity and examined its protective effect against cisplatin nephropathy both in vivo and in vitro in cisplatin-stimulated tubular epithelial cells (TECs). Our results showed that Cpd-6c restored renal function more effectively than Ru, as evidenced by reduced blood urea nitrogen and … howard leight headphones bluetooth